I'm counting comic books amongst my 50 book total.
The reason I started with this one was just because this was the earliest in the comic book store I looked in; I'm now borrowing the book with issues #1-5 in it so hopefully that will cause things to make more sense. This is set after the ninth season of the show (and presumably the second movie too). Anyhow, spoilers...
[Spoiler (click to open)]
The comic book opens with Scully attempting to save Mulder's life after he has been shot; there is a lot of spooky stuff going on, including some apparent illuminate-like cult following them, and since this is the last story in a five-part serial, it quickly leads to a climactic confrontation with an alien bounty hunter.
The second half or so of the story is all about wrapping stuff up, which includes Scully enlisting in the F.B.I. again and an appearance from the show's chief antagonist, the Cigarette-Smoking Man, evidently having somehow survived being nuked at the end of the show's run on the television - he is speaking to someone whose face isn't seen properly, but who is evidently meant to look like Walter Skinner (now promoted to Deputy Director); I suspect this is probably a red herring.
Overall, this seems quite good; most of what happens seems quite open-ended, and raises lots of questions, much like many of the alien-based stories that were on the show itself. The front cover is excellent, though I had mixed feelings about the artwork inside; some of it is really good, while some seems too dark and grainy, and you can barely see anyones' faces properly. Some of the pictures of Mulder looked nothing like David Duchovny.
However, based on this, it feels like the comic book series could have a long lifespan.
Next book: Unseen Academicals (Terry Pratchett)